This strange DNA event recording system can track cellular activity from birth to death

What is DNA Event Recording and how does it work?

Using advanced CRISPR-mediated DNA editing and genome engineering techniques, scientists can introduce a region of synthetic DNA into an animal’s DNA. This region contains “genetically coded DNA barcode arrays” called DNA bands that record cellular changes in the form of mutations. Later, these recordings can be retrieved via DNA sequencing.

DNA bands are only one part of the DNA event registration system. It also includes a molecular machine (a molecular video camera) to detect what is happening inside and outside the cell, a writing system to transmit this information to the synthetic DNA strip by reorienting the genome editing technologies and a reader that reconstructs biological history (from recorded mutations) using DNA sequencing and high performance computing.

According to the researchers, this whole DNA event registration system targets regions of synthetic DNA and therefore does not affect the original DNA or the native biological system. Moreover, it is also likely to solve the major problem with studying cell activity, i.e. killing animals of the same species over and over again to study the changes that occur at different stages. of life. In-cell recording would require us to sacrifice an animal only once at the endpoint to see information about the history of previous events.

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