No chemotherapy needed to treat cancer, new research finds

A team of 11 scientists from the Cleveland Clinic in the United States and a researcher from the University of Allahabad (AU) have found a way in which chemotherapy and radiation therapy will not be necessary to kill cancer cells.

The work of the team led by Yang Li, professor of cancer biology at the Cleveland Clinic, and assisted by Munish Pandey, assistant professor in the department of biochemistry, AU, has been published in the prestigious journal “Oncogene by Nature”.

The research is important because the work promises a treatment that will spare cancer patients from the side effects of chemotherapy and radiation therapy.

After its successful experiment on rats, efforts are now being intensified to apply it to the human body.

Pandey said, “The study may provide relief to cancer patients who undergo chemotherapy. Chemotherapy uses radiation and other drugs that have many side effects and evoke the immune system which causes severe pain and an allergic reaction. L The team has already developed knockout mice for miR-21 and the same has been published in the US journal “Proceedings of the National Academy of Sciences” (PNAS). MicroRNA-21 (small non-coding RNA) is one of the most abundant microRNAs in mammalian cells that regulates apoptosis (cell death program) and oncogenic effects.

“I worked with American scientists and invented an alternative to chemotherapy and drugs in the treatment of cancer, which damage normal cells as well as cancer cells during cancer treatment. This successful experiment was carried out by a team of 11 scientists from the Cleveland Clinic and Yang Li. Our team, in experiments with mice, injected its antisense into mice to make miR-21 ineffective. “

As a result, it was found that the tumor formed in the rat’s body gradually got smaller, and some tumors disappeared completely.

This experience lasted a year in America. However, it has not yet been used on the human body. Now the effort has been stepped up to apply it to the human body, Pandey said.

He added that due to cancer, tumors form in the body which are removed by chemotherapy and drugs. In this process of treatment with cancer cells, normal cells are also damaged and have a negative effect on the body.

The group is working on other mechanisms of programmed cell death, microRNAs and chimeric antigen T cell therapy to fight carcinogenicity in mice.

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Posted on: Sunday December 26th, 2021 03:26 PM IST

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